Table 5.
HLA Class II associations with dcSSc
| HLA | Ctrl, n (%) | dcSSc, n (%) | Uncorrected P | Corrected P | OR (CI95) |
|---|---|---|---|---|---|
| Italy | |||||
| DRB1*1104 | 83 (10.4) | 38 (20.2) | <0.001 | 0.001 | 2.182 (1.43, 3.329) |
| DQA*0501 | 250 (31.3) | 87 (46.3) | <0.001 | <0.001 | 1.888 (1.366, 2.609) |
| DQB*03 | 301 (37.7) | 95 (50.5) | 0.001 | 0.02 | 1.687 (1.225, 2.322) |
| Spain | |||||
| DRB1*01 | 255 (13.8) | 12 (5.2) | <0.001 | 0.004 | 0.343 (0.189, 0.622) |
| DRB1*0402 | 27 (1.5) | 11 (4.8) | <0.001 | 0.02 | 3.38 (1.654, 6.909) |
| DRB1*1104 | 20 (1.1) | 26 (11.3) | <0.001 | <0.001 | 11.623 (6.375, 21.193) |
| DRB1*11 | 230 (12.5) | 49 (21.3) | <0.001 | 0.004 | 1.9 (1.346, 2.681) |
| DRB1*15 | 165 (8.9) | 36 (15.7) | 0.001 | 0.02 | 1.883 (1.278, 2.789) |
| DQB*0501 | 291 (15.8) | 14 (6.1) | <0.001 | 0.008 | 0.346 (0.199, 0.602) |
| DQB*05 | 358 (19.4) | 23 (10) | <0.001 | 0.007 | 0.461 (0.295, 0.72) |
HLA Class II significant associations with the diffuse cutaneous subset (dcSSc) (after 10 000-fold permutation testing) in Italy and Spain. Total number of alleles per series: Italy, dcSSc = 188; controls = 798; Spain, dcSSc = 230; Ctrl = 1844. Ctrl: control.