Table 6.
HLA Class II associations with lcSSc
| HLA | Ctrl, n (%) | lcSSc, n (%) | Uncorrected P | Corrected P | OR (CI95) |
|---|---|---|---|---|---|
| Italy | |||||
| DRB1*1104 | 83 (10.4) | 100 (18.5) | <0.001 | <0.001 | 1.949 (1.423, 2.669) |
| DQA*0501 | 250 (31.3) | 231 (42.6) | <0.001 | <0.001 | 1.628 (1.298, 2.042) |
| DQA*05 | 326 (40.8) | 274 (50.5) | <0.001 | 0.01 | 1.48 (1.188, 1.844) |
| Spain | |||||
| DRB1*0701 | 283 (15.3) | 59 (9.1) | <0.001 | 0.003 | 0.055 (0.412, 0.745) |
| DRB1*0801 | 46 (2.5) | 36 (5.6) | <0.001 | 0.004 | 2.307 (1.477, 3.602) |
| DRB1*1104 | 20 (1.1) | 38 (5.9) | <0.001 | <0.001 | 5.7 (3.291, 9.871) |
| DRB1*1301 | 135 (7.3) | 22 (3.4) | <0.001 | 0.01 | 0.446 (0.282, 0.707) |
| DQA*0103 | 158 (8.6) | 26 (4.0) | <0.001 | 0.004 | 0.447 (0.293, 0.684) |
| DQA*0401 | 58 (3.1) | 43 (6.7) | <0.001 | 0.003 | 2.196 (1.464, 3.293) |
| DQB*0402 | 61 (3.3) | 44 (6.8) | <0.001 | 0.004 | 2.136 (1.434, 3.182) |
| DQB*05 | 358 (19.4) | 163 (25.3) | 0.002 | 0.02 | 1.401 (1.133, 1.731) |
HLA Class II significant associations with the limited cutaneous subset (lcSSc) (after 10 000-fold permutation testing) in Italy and Spain. Total number of alleles per series—Italy: lcSSc = 542; Ctrl = 798; Spain: lcSSc = 646; Ctrl = 1844. Ctrl: controls.