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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Alcohol Clin Exp Res. 2011 May 25;35(10):1739–1748. doi: 10.1111/j.1530-0277.2011.01520.x

Figure 2.

Figure 2

Impaired frontostriatal connectivity in alcohol-dependent patients (see Park et al., 2010).

A: A functional connectivity analysis with ventral striatum as seed region revealed an impaired connectivity with the dorsolateral prefrontal cortex (DLPFC) during a reversal learning paradigm.

B: A multiple regression analysis showed a negative relationship between learning speed and the frontostriatal connectivity modulation: The smaller the feedback-related connectivity modulation, the more trials were required to learn the rule.

C: The greater the self-reported craving for alcohol the less pronounced was the connectivity modulation.