Table 3.
Multivariate analysis (Cox proportional hazards model) for overall population
| Variable | HR for OS (95% CI) | P value | HR for RFS (95% CI) | P value |
| Age | 1.023 (1.006–1.040)a | 0.0066 | 1.019 (1.004–1.033) | 0.0108 |
| Histology | ||||
| ADC versus SCC | 0.706 (0.515–0.969) | 0.0313 | 0.760 (0.575–1.005) | 0.0546 |
| Gender | ||||
| Male versus female | 1.476 (1.081–2.017) | 0.0144 | 1.388 (1.055–1.826) | 0.0190 |
| Stage | ||||
| II versus I | 1.761 (1.238–2.503) | 0.0016 | 1.756 (1.289–2.392) | 0.0004 |
| III/IV versus I | 2.753 (1.709–4.435) | <0.0001 | 2.530 (1.624–3.942) | <0.0001 |
| Any treatment versus none | 1.228 (0.877–1.718) | 0.23 | 1.344 (0.998–1.810) | 0.0519 |
| pAMPK | ||||
| Positive versus negative | 0.608 (0.444–0.832) | 0.0006 | 0.624 (0.427–0.825) | 0.0009 |
P values are calculated by Cox proportional hazards model.
a
Risk of death 1.023 times higher for each year increase.
HR, hazard ratio; OS, overall survival; CI, confidence interval; RFS, recurrence-free survival; ADC, adenocarcinoma; SCC, squamous cell carcinoma; pAMPK, phosphorylated AMP-activated protein kinase.