Table 4.

Multivariate analysis (Cox proportional hazards model) for OS and RFS in patients with adenocarcinoma (N = 299)

Variable	HR for OS (95% CI)	P value	HR for RFS (95% CI)	P value
Age	1.026 (1.004–1.048)	0.0192	1.020 (1.002–1.039)	0.0317
Gender
Male versus female	1.909 (1.265–2.880)	0.0021	1.571 (1.106–2.230)	0.0116
Stage
II versus I	2.154 (1.346–3.445)	0.0014	1.925 (1.288–2.878)	0.0014
III/IV versus I	2.294 (1.247–4.219)	0.0076	2.073 (1.198–3.585)	0.0091
Any treatment versus none	1.056 (0.678–1.644)	0.81	1.324 (0.902–1.945)	0.15
pAMPK
Positive versus negative	0.459 (0.307–0.688)	0.0002	0.574 (0.402–0.818)	0.0021

P values are calculated by Cox proportional hazards model.

OS, overall survival; RFS, recurrence-free survival; HR, hazard ratio; CI, confidence interval; pAMPK, phosphorylated AMP-activated protein kinase.