Table 4.
False-positive risk and cancer detection by women's characteristics (adjusted by screening-protocol characteristics) (N = 2 777 429)
| Screening mammograms | Multivariate analysis (OR, 95% CI)a |
|||
| False-positive risk (all procedures) | False-positive risk (invasive procedures) | Cancer detection | ||
| Age at screening (years) | ||||
| 44–49 | 469 047 | 1.50 (1.46–1.54)b | 1.44 (1.30–1.58)b | 0.39 (0.35–0.43)b |
| 50–54 | 699 256 | 1.26 (1.23–1.29)b | 1.26 (1.15–1.37)b | 0.48 (0.44–0.52)b |
| 55–59 | 695 921 | 1.13 (1.10–1.16) | 1.06 (0.97–1.16) | 0.67 (0.62–0.73)b |
| 60–64 | 633 845 | 1.06 (1.03–1.09) | 0.96 (0.88–1.06) | 0.84 (0.77–0.90)b |
| 65–69 | 279 360 | Ref. | Ref. | Ref. |
| HRT | ||||
| No | 2 485 550 | Ref. | Ref. | Ref. |
| Yes | 291 879 | 1.03 (1.01–1.05)b | 0.84 (0.78–0.90)b | 0.86 (0.80–0.94)b |
| Menopause | ||||
| Menopausal | 2 157 627 | Ref. | Ref. | Ref. |
| Premenopausal | 619 802 | 1.31 (1.29–1.33)b | 1.22 (1.16–1.29)b | 1.16 (1.07–1.25)b |
| Previous invasive procedure | ||||
| No | 2 585 871 | Ref. | Ref. | Ref. |
| Yes | 191 558 | 1.52 (1.49–1.56)b | 2.00 (1.89–2.12)b | 1.31 (1.20–1.42)b |
| Familial breast cancer | ||||
| No | 2 581 981 | Ref. | Ref. | Ref. |
| Yes | 195 448 | 1.18 (1.15–1.20)b | 1.21 (1.13–1.30)b | 1.66 (1.55–1.79)b |
Menopause: pre-/perimenopausal or menopausal status; previous invasive procedure: personal previous invasive procedure; familial breast cancer: first-degree familial history of breast cancer previously described.
a
Multivariate analysis adjusted by women's screening number, screening period, radiology unit (random effect) and reading-protocol variables (reading method, number of views, mammography type).
b
Significant at the 95% CI.
OR, odds ratio; CI, confidence interval; HRT, hormone replacement therapy.