Fig. 2.

ITC metabolism via the mercapturic acid pathway. ITCs first react with GSH to form GS conjugates, which are promoted by glutathione S-transferase (GST). The conjugates undergo successive enzymatic modifications, first by γ-glutamyltranspeptidase (GT) to form cysteinylglycine–ITC conjugates, then by cysteinylglycinase (CG) to form the cysteine–ITC conjugates and finally by N-acetyltransferase (AT) to form the NAC–ITC conjugates.