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Decreased locomotor activity of Apc+/− mice 8–9 weeks of age in an open-field test. (A) Total distance was significantly decreased in Apc+/− mice compared to wild-type mice in the first 30 min and in the entire 60 min. (B) Vertical activity of Apc+/− mice was significantly decreased. Apc+/− mice showed a slight, but not significant, decrease in time spent in the center area (C), and stereotypic counts (D). Apc+/− mice, n = 18; wild-type mice, n = 22.
