Table 2.
General health, neurological reflexes, and sensory and motor abilities in Apc+/− mice (+/−) and wild-type littermate controls (+/+).
| +/+ | +/− | |
|---|---|---|
| PHYSICAL CHARACTERISTICS | ||
| Weight (g) | 22.8 (±0.5) | 20.9 (±0.3)** |
| Whiskers (% with) | 100 | 100 |
| Fur (% with normal far) | 95 | 100 |
| Body temperature (°C) | 36.9 (±0.2) | 36.5 (±0.2) |
| SENSORY MOTOR REFLEX | ||
| Ear twitch (% with quick response) | 100 | 100 |
| Whisker twitch (% with normal response) | 100 | 100 |
| Righting reflex (% with normal response) | 100 | 100 |
| PAIN TESTS | ||
| Hot plate (latency; s) | 7.9 (±0.4) | 8.7 (±0.5) |
| MOTOR TESTS | ||
| Wire hang | ||
| (Latency to fall; s) | 58.8 (±1.0) | 56.8 (±1.9) |
| Grip strength (N) | 0.816 (±0.018) | 0.792 (±0.02) |
| Rotarod | ||
| (Latency to fall; s) | 104.4 (±12.5) | 112.1 (±17.0) |
| 128.9 (±9.9) | 139.8 (±12.2) | |
| 144.1 (±12.4) | 152.8 (±12.8) | |
| 155.6 (±14.9) | 158.1 (±15.4) | |
| 178.0 (±16.4) | 176.7 (±15.2) | |
| 149.9 (±17.4) | 179.5 (±16.2) | |
Apc+/− mice, n = 18; wild-type mice, n = 22.
**p = 0.0030, compared to wild-type.