Figure 4.

Cortical (A) densities and (B) areas in wildtype (wt) and BERKO (−/−) mice after ovariectomy (ovx) or sham surgery at the age of 3 mo. The reduction in cortical density after ovariectomy did not differ significantly between wild-type and BERKO mice; however, cortical area was significantly smaller in wild-type than BERKO mice. *, P < 0.05 compared with value for intact mice of the same genotype; +, P < 0.05 compared with value for respective wildtype mice; #, P < 0.05 compared with value at 3 mo for mice of the same genotype. Black bars represent the mean value of WT at 3 mo of age (also shown as bar furthest to the left).