Table 1.
Baseline characteristics and serum levels of MMP-2, MMP-3, MMP-9 and TIMP-1 in hypertensive patients with sinus rhythm, paroxysmal and permanent AF
| Variables | Sinus Rhythm (n = 27) | Paroxysmal AF (n = 33) | Permanent AF (n = 26) | P Value |
|---|---|---|---|---|
| Age ± SD (years) | 62.74 ± 7.20 | 69.51 ± 9.39 | 68.31 ± 8.25 | 0.007 |
| Gender (Males/Females) | 17/10 | 16/17 | 14/12 | 0.53 |
| BMI ± SD (kg/m2) | 29.78 ± 4.15 | 27.92 ± 4.05 | 28.92 ± 4.50 | 0.24 |
| LVMI ± SD (g/m2) | 96.10 ± 17.48 | 92.87 ± 19.77 | 95.13 ± 10.79 | 0.86 |
| LA volume ± SD (mm3) | 52.10 ± 13.50 | 63.27 ± 18.70 | 94.73 ± 25.14 | < 0.001 |
| LA volume/BSA ± SD (mm3/m2) | 26.68 ± 7.32 | 33.81 ± 10.15 | 50.15 ± 14.43 | < 0.001 |
| LVEF (%), median (IQR) | 65.0 (60.0-65.0) | 62.0 (60.0-65.0) | 61.0 (55.0-65.0) | 0.045 |
| SBP (mmHg), median (IQR) | 132.67 ± 11.44 | 131.12 ± 13.446 | 133.54 ± 9.95 | 0.73 |
| DBP (mmHg), median (IQR) | 77.11 ± 5.76 | 78.05 ± 6.40 | 78.23 ± 6.07 | 0.77 |
| MMP-2 (pg/ml), median (IQR) | 37.00 (32.00-43.90) | 206.20 (111.80-371.35) | 36.23 (21.40-60.38) | < 0.001 |
| MMP-3 (ng/ml), median (IQR) | 10.61 ± 4.93 | 18.91 ± 4.77 | 17.52 ± 7.01 | < 0.001 |
| MMP-9 (pg/ml), median (IQR) | 86.00 (34.00-232.50) | 114.25 (55.25-187.53) | 368.75 (275.63-575.00) | < 0.001 |
| TIMP-1 (ng/ml), median (IQR) | 3.06 (1.23-3.87) | 0.58 (0.39-0.81) | 0.42 (0.27-0.51) | < 0.001 |
BMI, body mass index; LVMI, left ventricular mass index; LA, left atrium; LVEF, left ventricular ejection fraction; SBP, systolic blood pressure; DBP, diastolic blood pressure; BSA, body surface area; SD, standard deviation; IQR, inter-quartile range