Table 2.
Baseline characteristics and serum levels of MMP-2, MMP-3, MMP-9 and TIMP-1 in the total cohort of AF patients and individuals with sinus rhythm
| Variables | Sinus Rhythm (n = 27) | AF (n = 59) | P Value |
|---|---|---|---|
| Age ± SD (years) | 62.74 ± 7.20 | 68.98 ± 8.85 | 0.002 |
| Gender (Males/Females) | 17/10 | 30/29 | 0.295 |
| BMI ± SD (kg/m2) | 29.78 ± 4.15 | 28.36 ± 4.24 | 0.15 |
| LVMI ± SD (g/m2) | 96.10 ± 17.48 | 93.89 ± 16.14 | 0.65 |
| LA volume ± SD (mm3) | 52.10 ± 13.50 | 77.13 ± 26.71 | < 0.001 |
| LA volume/BSA ± SD (mm3/m2) | 26.68 ± 7.32 | 41.01 ± 14.62 | < 0.001 |
| LVEF (%), median (IQR) | 65.0 (60.0-65.0) | 62.0 (60.0-65) | 0.02 |
| SBP (mmHg), median (IQR) | 132.67 ± 11.44 | 132.19 ± 11.99 | 0.47 |
| DBP (mmHg), median (IQR) | 77.11 ± 5.76 | 78.13 ± 6.20 | 0.86 |
| MMP-2 (pg/ml), median (IQR) | 37.00 (32.00-43.90) | 114.80 (37.20-338.35) | 0.001 |
| MMP-3 (ng/ml), median (IQR) | 10.61 ± 4.93 | 18.30 ± 5.85 | < 0.001 |
| MMP-9 (pg/ml), median (IQR) | 86.00 (34.00-232.50) | 189.40 (95.90-361.90) | 0.011 |
| TIMP-1 (ng/ml), median (IQR) | 3.06 (1.23-3.87) | 0.47 (0.36-0.73) | < 0.001 |
BMI, body mass index; LVMI, left ventricular mass index; LA, left atrium; LVEF, left ventricular ejection fraction; SBP, systolic blood pressure; DBP, diastolic blood pressure; BSA, body surface area; SD, standard deviation; IQR, inter-quartile range