Fig. 5.

DBKO mice are resistant to HFD-induced obesity. A: Growth curves of male mice fed HFD for the indicated period. Eight-week-old ob/ob and DBKO mice fed this diet were weighed weekly. Values represent mean ± SE (n = 8 of each genotype). B: Gross representative images of male ob/ob and DBKO mice before euthanization. C–F: Representative pictures and weights of iWAT, rWAT, BAT, and liver of HFD-fed male mice. G: Hematoxylin and eosin (H+E) staining and TG content of liver (magnification ×20) from ob/ob and DBKO mice. H: Glucose/insulin ratio. Values are the means ± SE of ob/ob and DBKO mice (n = 6). *P < 0.05; **P < 0.01.