Fig. 9.

PKCβ-dependent modulation of β3-AR signaling in iWAT. A: Expression levels of β-AR subtypes in ob/ob and DBKO mice fed HFD for 8 weeks, which were normalized to the expression level in ob/ob mice. Levels for each gene in ob/ob were assigned a value of 1. B: Adipose tissues explants were isolated from ob/ob and DBKO mice. Subsequently, explants were treated with LY333,531 or vehicle. Explants from the same mice were treated with both experimental conditions. Expressions of β-ARs were determined in the explants. Data are represented as means ± SD (n = 5 mice per group). * P < 0.05; **P < 0.01.