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Analyses of metabolites by HPLC and LC-MS. (A) Time-course metabolism by CYP3A4. The incubations were performed at 37°C with 1 pmol CYP3A4 and 10 μM Z-guggulsterone for 0–120 min. The HPLC elution trace was generated at 240 nm. (B–E) HPLC chromatogram and full scan of metabolites M1, M2, M3, and M4, respectively.
