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. 2012 Feb 9;7(2):e31993. doi: 10.1371/journal.pone.0031993

Figure 4. Lithium treatment does not alter neuronal loss in the APPSwDI/NOS2−/− mice.

Figure 4

Panels A–F show Nissl staining for wildtype (A and D), APPSwDI/NOS2−/− mice receiving control diet (B and E) and APPSwDI/NOS2−/− mice receiving lithium diet (C and F). Panels A–C show the whole hippocampus at 40× magnification (scale bar in A for A–C = 120 µm). Panels D–F show the CA3 region of the hippocampus at 100× magnification (scale bar in D for D–F = 50 µm). Panel G shows stereological counts of neuron number in the subiculum and CA3 of wildtype mice and APPSwDI/NOS2−/− mice receiving either control diet or lithium diet. ** indicates P<0.01 compared to wildtype mice.