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. 2012 Feb 9;8(2):e1002383. doi: 10.1371/journal.pcbi.1002383

Table 2. Diffusion constants for diffusible molecules in the model.

Molecule Name Diffusion Constant (µm2/sec)
Ca 174.3
Calbindin 9.3
CalbindinCa 9.3
Da 150
ATP 74.7
AMP 85.5
cAMP 86.4
Cam 11
CamCa2 11
CamCa4 11
CaMKIICamCa4 3.6
pCaMKIICamCa4 3.6
CaMKII 3.6
pCaMKII 3.6
PKAc 8.1
DARPP32 10.6
DARPP32-PKAc 10.6
pT34-DARPP32 10.6
pT75-DARPP32 10.6
pT75-DARPP32-PKAc 10.6

Molecules not listed do not diffuse; thus, their diffusion constants are zero. To calculate diffusion coefficients as in [57] we used a cytosolic viscosity of 4.1 for small molecules and a cytosolic viscosity of ∼8.7 for proteins . These values yielded calcium gradients similar to those measured experimentally [59], and diffusion constants similar to those measured experimentally [50].