TABLE C1. A summary of related approaches to the coalescence process in the presence of purifying selection.

	This work	Kaplan et al. (1988)	Hudson and Kaplan (1994, 1995)	Gordo et al. (2002)	Charlesworth et al. (1993)	Barton and Etheridge (2004)	Seger et al. (2010)	O’Fallon et al. (2010)
Analytical expressions for genealogy structure	x				x	x		x
Accounts for frequency class fluctuations (valid for Ns ∼1)		x				x	x	xa
Valid for Nse−U/s ≪ ln [U/s]	x	x	x	x		x	x	x
Valid for Ns ≫ 1	x	x	x	x	x	x	x
Valid for many classes	x	x	x	x	x		x	x
Accounts for Muller's ratchet		x				xb	x
Discrete fitness classes	x	x	x	x	x	x	x

^aAddresses Ns ∼1 situation, but assumes deterministic fitness distribution.

^bWithin a two-class framework.