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. Author manuscript; available in PMC: 2012 Aug 9.
Published in final edited form as: Nature. 2012 Feb 1;482(7384):179–185. doi: 10.1038/nature10809

Figure 1. Increased severity of NASH in inflammasome-deficient mice.

Figure 1

To induce NASH, mice were fed with MCDD for 24 d. Their serum ALT and AST activities measured and NAFLD histological activity scores were determined. (a–h) Comparison of ALT, AST, and NAFLD activity, plus histological scores for steatosis and inflammation between singly-housed wild-type (wt) mice and caspase-1−/− (a,b), Asc−/− (c,d), Nlrp3−/−(e,f), or Il18−/−(g,h). Data represent two independent experiments (n=7–19 mice/treatment group). Error bars represent the SEM of samples within a group. *p≤ 0.05, **p≤ 0.01, ***p≤ 0.001 (Student’s t test).