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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Glia. 2012 Jan 6;60(4):559–569. doi: 10.1002/glia.22289

Figure 2. LPS induces F4/80 positive cell activation in an APOE genotype dependent manner in the hippocampus.

Figure 2

APOE2, APOE3, APOE4 and APOE knock-out mice were sacrificed 24h and 72h after ICV injection of LPS (1000ng) or saline. (A) Representative IHC images of F4/80-positive microglia in the hippocampus under 5X and 63X lens (Inset). The scale bar is 100μm and 10μm, respectively. (B) Quantification of F4/80- positive cells in the hippocampus. The numbers of F4/80-positive microglia are expressed as mean ± SD (n=4-5/group). **P<0.01, compared with saline treatment at the same time point. ##P<0.01, compared with APOE2 or APOE3 at the same LPS treatment time point.