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. Author manuscript; available in PMC: 2012 Dec 28.
Published in final edited form as: Oncogene. 2011 Nov 7;31(26):3177–3189. doi: 10.1038/onc.2011.497

Figure 7.

Figure 7

Comparison of Bax/Bak-mediated cell death in HCT116 and MEF cells. (A-B) Caspase-3/7 activity in indicated MEF (A) or HCT116 (B) cell lines treated with 0.2 μM staurosporine. Fold change of caspase activity was normalized to untreated controls. The experiment was repeated twice and representative data were shown as average±SD. (C-D) Caspase-3/7 activity (C) or Cyt.c release (D) in indicated MEF cell lines treated with ABT-737. The experiment was repeated twice and representative data were shown as average±SD. (E-F) Cyt.c release in HCT116 (E) or MEF (F) cells transfected with GFP-tagged BH-3 only proteins and GFP-Bcl-xS for 24 hrs. GFP-C1 vector was used as a control. The experiment was repeated twice and representative data were shown as average±SD. The p-value was obtained using the Student’s t-test. *, p<0.05; **, p<0.01; ***, p<0.001.