Fig. 3.

Postulated chemokine dependent regulation of lectin and integrin receptor/ligand expression on immature Dendritic Cells and subsequent binding to brain endothelium. Chemokines CCL2-6 secreted from neurovascular unit of the blood brain barrier activate their respective G protein coupled receptors-CCR1-5/20 that can potentially be involved in increased transcription of genes encoding for lectins and integrins that can potentiate the adhesion and transmigration process. The molecules that participate in DC adhesion to endothelial cells are integrins (LFA-1 and VLA-4/5) and lectins (DC-SIGN). DCs interact with intercellular adhesion molecules ICAM-2 and ICAM-3, vascular cell adhesion molecule VCAM-1 and P/E-selectins present in the surface of endothelial cells, allowing and strengthening DC adhesion