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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Neurobiol Dis. 2011 Dec 11;45(3):902–912. doi: 10.1016/j.nbd.2011.12.007

Figure 5. EID1 Tg mice showed reduced hippocampal LTP and impaired spatial learning and memory function.

Figure 5

A. Hippocampal slices were prepared from three month old EID1 Tg and age matched control littermates as described in the Materials and Methods. At the time point of 30 min after induction of LTP, the amplitude of EPSC is 145.9 ± 7.2% of baseline for control mice (p < 0.001, vs. baseline, n=12 cells from 3 mice), and 106.1 ± 6.8% of baseline for Tg mice (p = 0.12, vs. baseline, n=11 cells from 3 mice). Note EID1 mice failed to induce LTP. B. Morris Water Maze test showing average latency to platform. EID1 Tg and control mice (15–19 month old, 8 each) were subjected to Morris Water Maze test for 10 days, 6–8 rounds/day. The escape latencies, swim distances, and swim speeds were statistically analyzed with the HVS Imaging software and plotted with Excel. C. Swimming path of EID1 Tg and control mice.