Table 1.
SE-encoding HLA-DRB1 allele frequencies in cases and controls
| DRB1 Allele |
TDM class |
European control Frequency in NMDP N =7870 |
NHW Controls N = 373 allele count (allele frequency) |
NHW Cases N = 149 allele count (allele frequency) |
OR (95%) | P |
|---|---|---|---|---|---|---|
| 0101 | S3P | 0.091 | 71 (0.095) | 44 (0.148) | 1.65 (1.08-2.51) | 0.014 |
| 0102 | S3P | 0.017 | 5 (0.007) | 2 (0.007) | 1 (0.13-5.82) | ns |
| 0401 | S2 | 0.091 | 64 (0.086) | 65 (0.218) | 2.97 (2.01-4.40) | <1×10−7 |
| 0404 | S3P | 0.036 | 28 (0.038) | 27 (0.091) | 2.55 (1.43-4.56) | 0.0005 |
| 0405 | S3P | 0.004 | 6 (0.008) | 9 (0.030) | 3.84 (1.24-12.24) | 0.007 |
| 0408 | S3P | 0.002 | 1 (0.001) | 8 (0.027) | 20.55 (2.61-440.0) | 0.00006 |
| 1001 | S3P | 0.008 | 5 (0.007) | 7 (0.023) | 3.56 (1.01-13.02) | 0.046 |
| 1303 | S2 | 0.010 | 11 (0.015) | 1 (0.003) | 0.22 (0.01-1.68) | ns |
| 1402 | S3P | 0.000 | 1 (0.001) | 0 (0.000) | - | ns |
| 1406 | S3P | 0.000 | 0 (0.000) | 0 (0.000) | - | - |
| Total | 0.260 | 192 (0.257) | 163 (0.547) | 3.48 (2.6-4.66) | <1×10−7 |
SE: Shared epitope;
NHW: Non-Hispanic White;
In the system described by Tezenas du Montcel (TDM) et al (4), HLA DRB1 alleles encoding SE were grouped according to amino acids sequence at 70-74 (S2 = QKRAA or DKRAA; S3P=QRRAA or RRRAA). All other alleles were designated as low risk (L) alleles.
NMDP: National Marrow Donor Program
OR = odds ratio; 95% CI: 95% confidence interval.