Fig. 5.

Correlation of muscarinic receptor subtype density with functional denervation. For each individual muscle strip the ratio of the carbachol maximum:EFS-induced contraction was determined. The average of the individual muscle strips for each experimental group for functional denervation is plotted vs. the immunoprecipitation data for M₂ receptor density (A) and M₃ receptor density (B). The ratio of the average carbachol maximum to the average EFS contraction displayed in Fig. 2 does not equal the average of the individual ratios for the strips. The density of M₂ receptors correlates with functional denervation. No correlation between the M₃ receptor density and functional denervation is seen.