. 2011 Dec 30;4(1):1–14. doi: 10.3390/toxins4010001

Table 3.

Acute toxicity of spirolides by feeding to mice.

Compound	State of alimentation	Vehicle	LD₅₀ (µg/kg body weight) ^a	LD₅₀ (µmol/kg body weight) ^a
Spirolide A	Fed	Cream cheese	1300 (1250–1580)	1.9 (1.8–2.3)
Spirolide C	Fed	Cream cheese	780 (ND)	1.1 (ND)
13-Desmethyl spirolide C	Fed	Cream cheese	1000 (861–1290)	1.5 (1.2–1.9)
20-Methyl spirolide G	Fed	Cream cheese	630 (476–882)	0.89 (0.68–1.3)
Spirolide A	Fasted	Cream cheese	1200 (1047–3690)	1.7 (1.5–5.4)
Spirolide C	Fasted	Cream cheese	500 (353–657)	0.71 (0.50–0.93)
13-Desmethyl spirolide C	Fasted	Dry mousefood	630 (547–829)	0.90 (0.79–1.2)
13-Desmethyl spirolide C	Fasted	Moist mousefood	590 (500–625)	0.85 (0.72–0.90)
13-Desmethyl spirolide C	Fasted	Cream cheese	500 (381–707)	0.72 (0.55–1.0)
20-Methyl spirolide G	Fasted	Cream cheese	500 (381–707)	0.71 (0.54–1.0)

^a Figures in brackets indicate 95% confidence intervals. ND: Not determined. In these cases, the pattern of deaths were such that the AOT program was unable to calculate confidence intervals.