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. 2012 Jan 17;109(5):1455-1460. doi: 10.1073/pnas.1114368109

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Fig. 5. — The tensin3/cten-DLC1 signaling pathway regulates cell migration and anchorage-independent cell growth. (A) Tensin3 and cten regulates cell migration via DLC1. MCF10A cells were transfected with the indicated siRNA oligos to deplete the corresponding proteins and plated in transwell chambers containing full medium without or with EGF (10 ng/mL) and Y27632 (10 μM). Percentage of migrating cells relative to cells with EGF stimulation was presented. Data shown are mean ± SD, n = 9. (B) DLC1 plays a key role in cellular transformation. HEK293 cells were transfected with the indicated constructs and incubated for 21 d in soft agar. The number of colonies formed for cells transfected with a specific construct was compared to that of the negative control cells, and the resulting percentage number was presented, with error bars representing standard deviation (SD, n = 3). Scrambled siRNA control, siCtrl.