Table 2.
Polycomb-related gene sets enriched with SWI/SNF subunit knockdown*
| siRNA target | Gene set | Description | Enrichment P value |
| ARID1A | NUYTTEN EZH2 TARGETS UP | Genes up-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 by RNAi | 4.55E-11 |
| SENESE HDAC1 TARGETS UP | Genes up-regulated in U2OS cells (osteosarcoma) on knockdown of HDAC1 by RNAi | 9.13E-09 | |
| SENESE HDAC3 TARGETS UP | Genes up-regulated in U2OS cells (osteosarcoma) on knockdown of HDAC3 by RNAi | 2.03E-07 | |
| SENESE HDAC2 TARGETS UP | Genes up-regulated in U2OS cells (osteosarcoma) on knockdown of HDAC2 by RNAi | 9.80E-05 | |
| ARID1B | NUYTTEN EZH2 TARGETS UP | Genes up-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 by RNAi | <10E-12 |
| SENESE HDAC3 TARGETS UP | Genes up-regulated in U2OS cells (osteosarcoma) on knockdown of HDAC3 by RNAi | 3.49E-08 | |
| SENESE HDAC1 AND HDAC2 TARGETS UP | Genes up-regulated in U2OS cells (osteosarcoma) on knockdown of both HDAC1 and HDAC2 by RNAi | 4.02E-06 | |
| KONDO EZH2 TARGETS | Genes up-regulated in PC3 cells (prostate cancer) after EZH2 knockdown by RNAi | 5.34E-06 | |
| SMARCA4 | NUYTTEN EZH2 TARGETS UP | Genes up-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 by RNAi | <10E-12 |
| SENESE HDAC3 TARGETS UP | Genes up-regulated in U2OS cells (osteosarcoma) on knockdown of HDAC3 by RNAi | 1.66E-11 | |
| KONDO EZH2 TARGETS | Genes up-regulated in PC3 cells (prostate cancer) after EZH2 knockdown by RNAi | 6.49E-07 |
*Gene sets shown are significantly enriched among the top 200 genes down-regulated with SWI/SNF subunit knockdown in HPDE cells.