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. 2012 Jan 4;109(5):E278–E287. doi: 10.1073/pnas.1113820109

Fig. 6.

Fig. 6.

RO25-6981 (2.0 μM) enhances evoked NMDAR responses through extrasynaptic GluN2B-containing NMDARs. Averaged time courses of NMDAR-isolated synaptic field potentials in dlBNST following 20 min of DL-APV (100 μM) in slices from naive adult male C57BL/6J mice (A), 60 min of Ro25-6981 (0.2, 2.0, or 10 μM) in slices from naive adult male C57BL/6J mice (B), 60 min of 2.0 μM Ro25-6981 in slices from GluN2B KO mice and representative data of 2.0 μM Ro25-6981 from B (C), 60 min of memantine (5 or 30 μM) in naive adult male C57BL/6J mice (D), memantine (1 or 5 μM) 20 min before and during 60 min of 2.0 μM Ro25-6981 in slices from naive adult male C57BL/6J mice (E), and representative data of 2.0 μM Ro25-6981 alone from B and 30 min of 2.0 μM Ro25-6981 in slices from naive adult male C57BL/6J mice under normal temperature (temp; ∼29 °C) or high temperature (∼36 °C) (F).