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Temporal neutralizing antibody response to AAV2.5. The temporal profile of the highest dilution of serum that neutralizes AAV2.5 transduction in vitro is shown for all six subjects. Subjects 1–3 received the same dose of AAV2.5 capsid, 6.6 × 1011 capsid particles. Subject 4 received 3.3 × 1012 capsid particles. Subjects 5 and 6 received 6.6 × 1012 capsid particles due to administration of empty capsid placebo (see Table 2). AAV, adeno-associated virus.
