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. 2012 Jan 30;3:9. doi: 10.3389/fphys.2012.00009

Figure 5.

Figure 5

Spermine-induced block of human (Hs) and dog (Cf) KIR2.2 channels. (A) Representative traces of KIR2.2 channel currents in the absence and presence of 0.1, 1, and 10 μM of spermine. Inset: pulse protocol, currents were elicit by 10 mV step test pulses from −60 to +90 mV. (B) Comparison of V–G relationships of human and dog KIR2.2. The scale of G/Gmax is logarithmic. Test pulses were applied in 5 mV steps from −60 to +90 mV, and G was calculated for each voltage. (C) The comparison of time constant of KIR2.2 channel currents at +80 mV in the presence of 1 and 10 μM SPM.