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A schematic model of small and large tumor cell clusters at the invasive margin in CRC and differences regarding proliferation (Ki-67) and expression of p16 in tumors with a normal or aberrant p16/cyclin D1/pRb pathway. The median LIs of Ki-67 and p16 in large and small tumor clusters are indicated for tumors with normal or aberrant p16/cyclin D1/pRb pathway.
