Table 1.
The Proliferative Activity (Ki-67) and p16 Expression in Relation to the Expression of Cell Cycle Regulatory Proteins
| Cell cycle status | Ki-67LARGE (median) | Ki-67SMALL (median) | Ki-67DIFF (median) | p16-positive (numbers) | p16-negative (numbers) | P value |
|---|---|---|---|---|---|---|
| pRb | ||||||
| Normal | 37.7 | 15.0 | 0.59 | 64 | 15 | NS |
| Inactivated | 49.0 * | 42.8 * | 0.14 | 2 | 0 | |
| Overexpression | 47.1 | 22.1 | 0.48 | 9 | 2 | |
| Cyclin D1 | ||||||
| Low | 40.7 | 15.2 | 0.59 | 26 | 3 | 0.043 |
| Normal | 37.7 | 14.5 | 0.61 | 38 | 9 | |
| Overexpression | 38.0 | 20.7 | 0.32 | 6 | 5 | |
| p16 | ||||||
| Negative | 38.7 | 29.1 ** | 0.26 ** | — | — | — |
| Positive | 38.7 | 14.5 | 0.61 | — | — | |
| p27 | ||||||
| Absent or low | 32.0 | 19.6 | 0.57 | 5 | 5 | 0.020 |
| High | 39.1 | 16.1 | 0.57 | 67 | 12 | |
| p53 Accumulation | ||||||
| Normal | 38.7 | 20.2 | 0.55 | 17 | 5 | NS |
| Abnormal | 38.7 | 14.8 | 0.59 | 57 | 12 |
Kruskal-Wallis test was used to analyze Ki-67 data (columns 2–4). Fisher’s exact test was performed to analyze p16 data (columns 5–7).
*P < 0.05.
**P < 0.01.