Figure 4.

Ndufs4–DA mice do not develop Parkinsonism. (A) Body weights of 12-month-old Ndufs4–DA and control mice (n≥ 11). (B) Spontaneous horizontal (locomotion) and vertical (rearing) activity of Ndufs4–DA and control mice monitored over a period of 2 h at ages 6, 12, 18 and 24 months. No significant differences were found in either early exploratory behavior or after 1 h of acclimatization. (C) Performance (latency to fall) of 10- and 24-month-old mice on an accelerating Rotarod. Each mouse was given four trials and the average time was used. Open bars, controls; black bars, Ndufs4–DA knockouts. Data shown as mean ± s.e.m.