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. 2011 Nov 17;21(5):1124–1137. doi: 10.1093/hmg/ddr541

Figure 1.

Figure 1.

Bezafibrate restores the PGC-1α signaling pathway in R6/2 mice. (A) Relative expression of FL- and NT- isoforms of PGC-1α, PPARα, γ, δ, and the downstream target genes, NRF-1, Cyt c, Tfam, ATP synthase, as well as the oxidative stress response genes HO-1, Nrf-2 and Gpx-1 in brain of R6/2 mice on a standard diet or on the bezafibrate diet. The levels of each gene transcript were normalized to that of β-Actin and expressed as fold variation relative to the wild-type mice on a standard diet. The asterisks and symbols represent the significance levels calculated by unpaired, Student's two-tailed t-test: *P < 0.05 compared with the wild-type controls; §P < 0.05 compared with R6/2 controls (n = 5 and bars represent SEM). (B, C) Relative expression of FL-, NT-PGC-1α, PPARα, γ, δ, NRF-1, Cyt c, Tfam and ATP synthase in muscle (B) or BAT (C) of R6/2 mice on a standard diet or on the bezafibrate diet. β-Actin and wild-type mice on a standard diet were used as reference.