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. 2011 Nov 21;21(5):1172–1183. doi: 10.1093/hmg/ddr545

Figure 6.

Figure 6.

Model for the role of BLM in rRNA transcription. During RNA polymerase I-mediated 45S rRNA transcription, RNA–DNA hybrids may form between the nascent rRNA transcript and the template rDNA (28). We propose that BLM unwinds the RNA–DNA hybrid so that transcription and replication proceed unaffected. In the absence of BLM, the RNA–DNA hybrid may remain unresolved resulting in retardation of further rRNA transcription, stalling of transcription and replication forks, and the induction of recombination within the rDNA (37).