Table 2.
Correlation of DNA Hypomethylation at the D16Z3 Locus and at the D1Z1 Locus with Histological Features of and Changes in Chromosomes 16 and 1 in Breast Carcinoma
| Parameters | No. of cases (%) | |||
|---|---|---|---|---|
| DNA hypomethylation | ||||
| D16Z3 | P | D1Z1 | P | |
| A. Histological type | ||||
| Intraductal/predominantly intraductal carcinoma | 0/6 (0) | <0.0001 | 0/6 (0) | 0.0002 |
| IDC, papillotubular type | 0/12 (0) | 1/11 (9) | ||
| IDC, solid tubular type | 5/9 (56) | 5/7 (71) | ||
| IDC, scirrhous type | 6/10 (60) | 5/7 (71) | ||
| Invasive lobular carcinoma | 1/2 (50) | 1/2 (50) | ||
| B. Histological grade | ||||
| 1 | 0/7 (0) | 0.019 | 0/6 (0) | 0.044 |
| 2 | 3/15 (20) | 4/13 (31) | ||
| 3 | 9/17 (53) | 8/14 (57) | ||
| C. Clinical stage | ||||
| I | 2/11 (18) | NS | 4/9 (44) | NS |
| II | 7/21 (33) | 6/18 (33) | ||
| III,IV | 3/7 (43) | 2/6 (33) | ||
| D. Mean copy score at D16Z2 | ||||
| ≤ 3 | 4/23 (17) | 0.034 | 5/18 (28) | NS |
| ≥ 4 | 8/16 (50) | 7/15 (47) | ||
| E. Mean copy score at D1Z1 | ||||
| ≤ 3 | 2/15 (13) | 0.065 | 3/12 (25) | NS |
| ≥ 4 | 10/24 (42) | 9/21 (43) | ||
| F. der(16)t(1;16)/der(1;16) formation | ||||
| Present | 2/17 (12) | 0.036 | 3/16 (19) | 0.070 |
| Absent | 10/22 (45) | 9/17 (53) | ||
| G. 16q breakages | ||||
| Detected | 9/30 (30) | 9/26 (35) | ||
| der(16)t(1;16)-positive | 2/17 (12) | 0.019 | 3/16 (19) | 0.046 |
| der(16)t(1;16)-negative | 7/13 (54) | 6/10 (60) | ||
| Not detected | 3/9 (33) | 3/7 (43) | ||
IDC, invasive ductal carcinoma; NS, not significant.