Table 1.

Dogs treated with ²¹¹At-anti-CD45 mAb without marrow grafts

Dog ID	Age, mo	Weight, kg	211At, μCi/kg	211At, MBq/kg	Survival, wk	Cause of death	Pathology
H313	9	5.8	100	3.7	53	End of study	Normal*
H297	7	7.6	196	7.4	54	End of study	Normal*
H248	7	13.0	320	11.8	54	End of study	Normal*
H213	6	9.6	405	15.2	49	Increasing transfusion requirements	Histologic changes consistent with hemolytic anemia†
H290	7	8.0	458	17.0	20	Liver failure with ascites	Histologic changes in the liver‡
H289	11	7.2	618	22.9	17	Liver failure with ascites	Histologic changes in the liver‡

The total dose of anti-CD45 mAb was 0.5 mg/kg, whereof 10% was injected as unlabeled anti-CD45 mAb 1 hour before treatment with the radioimmunoconjugate.

^*No macroscopic or histologic evidence of radioactivity induced organ toxicity.

^†H213 was a pyruvate kinase deficiency carrier that developed increasing transfusion requirements during follow-up.

^‡Histologic examination of liver tissue revealed clusters of iron-laden macrophages scattered throughout the liver acinus and perivenular area.