Skip to main content
. 2011 Dec 7;119(5):1240–1247. doi: 10.1182/blood-2011-08-371690

Figure 2.

Figure 2

Prior administration of oral THU increases oral bioavailability and decreases interindividual variability in pharmacokinetics of DAC. (A) DAC concentration-time profiles in 8 baboons administered oral DAC 200 mg/m2 (10 mg/kg). (B) DAC concentration-time profiles in the same 8 baboons administered DAC at half the dose (100 mg/m2 [5 mg/kg]) 60 minutes after THU 400 mg/m2 (20 mg/kg; THU-DAC). PK measurements went to 180 instead of 240 minutes because of the allowable duration of anesthesia. (C) The largest increases in AUClast with coadministration of THU were seen in animals with lower intrinsic oral bioavailability of DAC. Histograms show the distribution of AUClast in 7 animals administered DAC alone versus the same 7 animals receiving DAC at half the dose after THU. AUC measurements went to 180 instead of 240 minutes in the THU-DAC group because of the allowable duration of anesthesia.