Table 1.
AUClast after oral DAC versus oral THU-DAC in the same baboons
| Weight, kg | AUClast, min/ng/mL* |
|||
|---|---|---|---|---|
| DAC, 200 mg/m2 alone | DAC, 100 mg/m2 alone | DAC 100 mg/m2 60 min after THU 400 mg/m2 | ||
| Baboon no. | ||||
| PA7482† | 12.3 | 49.98 | ND | Not quantifiable |
| PA7484 | 11.5 | 190.35 | 252.73 | 5621.05 |
| PA7256 | 19.8 | 299.02 | ND | 760.27 |
| PA7472 | 10.7 | 327.25 | ND | 444.825 |
| PA7254 | 14.4 | 463 | ND | 2587 |
| PA7255 | 19.9 | 807.8 | ND | 533.47 |
| PA7258 | 12.6 | 2863.6 | ND | 2284.48 |
| PA7470 | 9.6 | 6278.78 | 1219.98 | 7515.32 |
| Mean ± SD | 1604 ± 2262 | 2821 ± 2749 | ||
| Median ± IQR | 463 ± 2565 | 2284 ± 5088 | ||
| Median ± IQR per mg of DAC‡ | 160 ± 226 | 457 ± 1017 | ||
| AUClast variation | ∼ 30-fold | ∼ 14-fold | ||
| AUClast coefficient of variation | 1.41 | 0.97 | ||
ND indicates not done; and IQR, interquartile range.
*
AUClast calculated over 240 minutes for DAC alone and 180 minutes for THU-DAC.
†
Data from PA7482 were not included in calculations of mean, median, -fold variation, or coefficients of variation because levels were below the lower limit of quantification at multiple time points.
‡
Significantly different between the DAC-only group and the THU-DAC group (P = .02 by Wilcoxon test).