Figure 7.

Photodynamic therapy with chlorin e₆ conjugated with DTox-HMP-NLS-EGF MNT inhibits A431 human epidermoid carcinoma growth and enhances survival of tumor-bearing Balb/c ByJIco-nu/nu mice compared with free chlorin e₆. (A) A431 tumor growth, mean ± SEM; average tumor volumes are shown up to the last day when all animals were alive. (B) Kaplan-Meier survival curve.

Notes: Arrows indicate injection and illumination cycles; bars represent the mean ± SEM.

Abbreviations: MNT, modular nanotransporter; DTox, translocation domain of diphtheria toxin; HMP, Escherichia coli hemoglobin-like protein; NLS, nuclear localization sequence; EGF, epidermal growth factor; SEM, standard error of mean.