Fig. 1.

Percentage of the WT Apc allele compared with the Pirc mutant allele in gDNA (x axis) and cDNA (y axis) from either Rb9-Min (A) or F1-Pirc (B) adenomas (filled symbols) or normal epithelium (NE; open circles). Tumors within the designated significance boundaries maintain heterozygosity of the gDNA but have lost heterozygosity in their cDNA. Rb9-Min significance lines (0.5–0.99) are superimposed on each other. F1-Pirc tumors that were sequenced for Apc are represented as filled triangles.