Table 1.

Overview of participating institutions' EMR and biorepositories and recruitment models

Institution	Biorepository overview	Recruitment model	Repository size	EMR summary
Marshfield Clinic Research Foundation (Marshfield, Wisconsin, USA)	Personalized medicine research project: Geographically defined cohort within an integrated regional healthcare system	Population based	20 000 98% Caucasian	Comprehensive internally developed EMR since 1985 75% participants have 20+ years medical history
Northwestern University (Chicago, Illinois, USA)	Nugene project: Northwestern affiliated hospitals and outpatient clinics	Population based	10 000 12% AA 8% Hispanic	Comprehensive vendor-based inpatient (Cerner, Kansas City, Missouri, USA) and outpatient (Epic Systems, Verona, Wisconsin, USA) EMR since 2000 20+ years ICD-9 data
Vanderbilt University (Nashville, Tennessee, USA)	BioVU: Vanderbilt Clinic, diverse outpatient clinic	Population based	100 000 11% AA	35+ Years medical history data Comprehensive internally developed EMR since 2000
Group Health Cooperative (Seattle, Washington, USA)	GHC Biobank Alzheimer's disease patient registry and adult changes in thought study	Disease-specific cohort	4000 (>96% Caucasian)	Comprehensive vendor-based (Epic Systems) EMR since 2004 20+ years pharmacy data 15+ years ICD-9 data
Mayo Clinic (Rochester, Minnesota, USA)	Vascular diseases biorepository	Disease-specific cohort	3500 (>96% Caucasian)	Comprehensive internally developed EMR since 1995 40-year history of data extraction

AA, African ancestry; EMR, electronic medical record; GHC, Group Health Cooperative; ICD-9, International Classification of Diseases, version 9.