Table 1.
Top 10 most related diseases, based on similarity score, to Alzheimer's disease and Prader-Willi syndrome based on the vector space model approach
| Related disease | Simθ (G →dj) | Sim (d0 →dj) | Corroborating Medline entries |
| Alzheimer's disease | |||
| Alzheimer's disease | 2.09E-08 | 8.38E-08 | 57 297 |
| Disease models, animal | 2.08E-08 | 4.16E-08 | 2718 |
| Polycystic kidney diseases | 2.06E-08 | 4.11E-08 | 2 |
| Down's syndrome | 2.01E-08 | 4.02E-08 | 1153 |
| Williams Syndrome | 1.97E-08 | 3.93E-08 | 2 |
| Neoplasms | 1.94E-08 | 3.87E-08 | 665 |
| Chromosome deletion | 1.93E-08 | 3.86E-08 | 10 |
| Polyploidy | 1.86E-08 | 3.72E-08 | 4 |
| Chromosome inversion | 1.79E-08 | 3.57E-08 | 2 |
| Melanoma | 6.03E-09 | 2.41E-08 | 15 |
| Prader-Willi syndrome | |||
| Genetic predisposition to disease | 1.74E-17 | 3.48E-17 | 2407 |
| Angelman syndrome | 1.64E-17 | 3.27E-17 | 478 |
| Drug-induced liver injury | 1.74E-17 | 1.74E-17 | 0 |
| Glioma | 1.73E-17 | 1.73E-17 | 4 |
| Neuroblastoma | 1.63E-17 | 1.63E-17 | 7 |
| Lupus erythematosus, systemic | 1.63E-17 | 1.63E-17 | 1 |
| Adrenal gland neoplasms | 1.62E-17 | 1.62E-17 | 1 |
| Thyroid neoplasms | 1.62E-17 | 1.62E-17 | 0 |
| Chromosome breakage | 1.61E-17 | 1.61E-17 | 26 |
| Melanoma | 1.60E-17 | 1.60E-17 | 7 |
Respective gene–disease and disease–disease similarity scores are shown, as well as the number of corroborating Medline entries (as determined by performing MeSH-based searches using a Boolean ‘AND’ to identify citations associated with both the related disease and the query disease). Literature searches were performed in August 2011.