Figure 4. Surfaces of native and redesigned proteins.

From left to right, the native protein in cartoon representation, and spherical representations of the native protein, a current Rosetta redesign, and a reweighted Rosetta + hpatch-SASA redesign. Hydrophobic patches are colored according to size (largest to smallest: dark green, green, lime, pale green, gray). Oxygen and nitrogen atoms colored red and blue, respectively, and all other atoms are colored gold. Proteins shown are histidine-containing protein (1OPD), histidine-containing protein phosphotransfer domain (2A0B), uracil DNA glycosylase (3EUG), and toxic shock syndrome toxin-1 (3TSS). Figures created with PyMOL.