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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Proteins. 2011 Dec 16;80(3):825–838. doi: 10.1002/prot.23241

Table IV. Correlation coefficients for predicting changes in stability.

Correlation coefficients (R) and root mean square error (RMSE) between experimental and predicted ΔΔG for a set of 1210 protein mutants using the weight-optimized energy functions.

energy function R RMSE
current Rosetta weights 0.69 1.76
current Rosetta, fit refEs only 0.68 1.66
current + hpatch-SASA, fit refEs only 0.68 1.71
standard 0.61 2.18
standard + hpatch-SASA 0.63 2.27
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