Figure 1.
ACVR2B:Fc treatment for 12 weeks increases body weight (A) and lean mass (B) without decreasing fat mass (C) in mice fed a HFD for 12 weeks before and after treatment. The mass of triceps, quadriceps and gastrocnemius skeletal muscles (D) increased with ACVR2B:Fc treatment. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, student’s t test; bracket in (B) denotes significance by repeated measures ANOVA.