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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Mol Cancer Ther. 2011 Dec 21;11(2):288–297. doi: 10.1158/1535-7163.MCT-11-0490

Figure 4. Combined inhibition of FAK and c-Met by small molecule kinase inhibitors inhibits medulloblastoma cell migration more than single inhibitions.

Figure 4

DAOY or DAOY-HGF cells were treated with either 1 μM FAKi, 100 nM METi, a combination of both, or control vehicle for 1 hour prior to treatment with or without 20 ng/ml HGF (DAOY only), for 24 hours. The cells were assessed for migration using the scratch assay. Cells that migrated into the scratch were photographed at 40X magnification. The results show that combined inhibition of FAK and c-Met has greater inhibitory effects on medulloblastoma cell migration than single inhibitions.