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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Autoimmun. 2011 Dec 7;38(1):1–9. doi: 10.1016/j.jaut.2011.09.004

Figure 5. Estrogen downregulates RAG expression through IL-6/IL-7R.

Figure 5

BALB/c mice (3-month-old) were ovariectomized and implanted with either estradiol (E2) or placebo pellets subcutaneously. Mice were rested 7–10 days and then immunized with DWEYS-MAP as described in Material and Methods. On day 17, antigen-specific B cells were isolated and RNA was extracted for qPCR to assess mRNA levels of RAG, IL-7R and IL-6.