Table 2.

Summary of signals regulated by, and effect of suppressor of cytokine signalling (SOCS) proteins during CD4⁺ T-cell polarization

			Effect
CD4+ lineage	SOCS protein	Signal regulated	Signal	Polarization	References
Thl	SOCS1	IFN-γ/STAT1	Inhibition	−	30,31
	SOCS3	IL-12/STAT4	Inhibition	−	33
Th2	SOCS1	IL-4/STAT6	Inhibition	−	31
	SOCS5	IL-4/STAT6	Inhibition	−/NC	37,39
	SOCS3	IL-12/STAT4	Inhibition	+	33,39
	SOCS2	IL-2/STAT5	Inhibition	−	59
		IL-6/STAT3	Enhancement	−	59
Thl7	SOCS3	IL-6/STAT3	Inhibition	−	72
		IL-23/STAT3	Inhibition	−	62
	SOCS1	IFN-γ/STAT1	Inhibition	+	61
		IL-6/STAT3	Enhancement	+	61
	SOCS2	IL-6/STAT3	Enhancement	+	59
Foxp3+ Treg	SOCS1	IL-2/STAT5	Inhibition	−/+	82,83

IFN, interferon; IL-12, interleukin-12; NC, not clear; STAT, signal transducer and activator of transcription; Th1, T helper type 1.